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No obvious physiological and behavioral phenotypes were observed for Glu-Cre;Vhl f/f mice.
Variable behavioral phenotypes were observed depending on the line and genetic background of the mice.
In addition, no abnormal motor, sensory, anxiety, or cognitive behavioral phenotypes were observed.
Despite a highly localized neurodevelopmental expression pattern in the SVZ, RMS, OB, and cortex, no defects in neuronal migration or anatomy were identified in Visc-2−/− animals, and no abnormal anxiety or cognitive behavioral phenotypes were observed.
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No circadian behavioral phenotype was observed in the Aβ42ArcM-expressing animals, suggesting that some function of the ventral lateral neurons, but not necessarily the clock in them, is important for regulating fat body triglycerides (Table 1).
In these pan-neuronally SOD1-expressing worms, a reduced locomotive behavioral phenotype is observed in mutant SOD1-expressing nematodes, whereas no defect was evident with WT-SOD1-expressing or control animals (Wang et al., 2009).
Two concentration-dependent phenotypes were observed.
The phenotypes were observed 2 weeks later.
Multiple locomotor phenotypes were observed.
However, different phenotypes were observed.
Furthermore, this abnormal phenotype was observed in other behavioral tests, such as the Y-maze test.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com