Crawley, J. N. & Paylor, R. A proposed test battery and constellations of specific behavioral paradigms to investigate the behavioral phenotypes of transgenic and knockout mice.
Karl, T., Pabst, R. & von Horsten, S. Behavioral phenotyping of mice in pharmacological and toxicological research.
Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests.
Crawley, J. N. Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests.
In conclusion, although specific facial dysmorphism and internal malformations are usually absent in individuals with GRIN2B mutations, there does seem to be a characteristic behavioral phenotype consisting of ID, hyperactivity, impulsivity and distractibility.
Prenatal cocaine exposure has been associated with numerous behavioral phenotypes in clinical populations, including impulsivity, reduced attention, alterations in social behaviors, and delayed language and sensory-motor development.
As regards psychological traits, the FTO alleles are highly expressed in the hypothalamus of the central nervous system and are known to be related with behavioral phenotypes such as increased food impulsivity and better emotional control in childhood [ 41], which appears to be conflicting with the personality of the SE type.
A potential explanation for the cEPOR TG phenotype of impulsivity and hyperactivity might be the continuous stimulation of the EPO system exclusively in cortical projection neurons.
Lack of effect on impulsivity stands in contrast to other studies in which other psychoactive drugs including ethanol, delta-9-tetrahydrocannabinol, and amphetamine altered behavior on one or more behavioral measures of impulsivity.
This is one of the first studies to examine both self-report and behavioral measures of impulsivity in bipolar disorder and schizophrenia.
