Sentence examples for behavioral phenotypes observed in from inspiring English sources
Various experiments revealed behavioral abnormalities in these mice, including increased depression-like and disinhibition-like behavior, in addition to impaired cognitive behavior in older animals, all of which are behavioral phenotypes observed in FTLD patients [ 72].
MBD5 may activate gene transcription to influence neuronal maturation and contribute to the behavioral phenotypes observed in Mbd5 +/GT To address how reduced expression of MBD5 might cause the observed neurological phenotypes, Camerena and colleagues cultured cortical neurons isolated from Mbd5 +/GT embryos and observed a distinct cellular phenotype.
Intriguingly, the neuronal subtypes that are specifically affected in mutant larvae provide a potential physiological basis for the behavioral phenotypes observed in both zebrafish and humans.
However, genetic inactivation of GSK3α results in a rescue of the behavioral phenotypes observed in L100P mice, and partially rescues the histological phenotype.
Ts65Dn is the most widely studied mouse model and recapitulates some aspects of brain morphology and behavioral phenotypes observed in people with DS (Reeves et al., 1995).
Only very strong promoters and the presence of multiple mutations in mice, a combination never occuring in AD patients, triggers most of the neuropathological and behavioral phenotypes observed in humans, albeit in very young animals [ 15].
This finding is opposite to the behavioral phenotype observed in Cdc42 f/f : Camk2a-Cre mice.
SH2B1α variant carriers were hyperinsulinemic but did not exhibit the behavioral phenotype observed in individuals with SH2B1 variants that disrupt all isoforms.
Thus, the alterations of dendritic spines which we found may well reflect part of the behavioral phenotype observed in these mice.
The behavioral phenotypes observed are provided in Supplemental Fig. S1.
Given the decreased penetrance and marked variability in expression for the behavioral phenotypes observed with deletion and duplication of the 22q11.2 region, it is likely that any causal gene in the region would have decreased penetrance as well.
