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(C ) 2BΔCtx exhibited a strong anxiolytic behavioral phenotype compared to control animals as measured in the elevated plus maze (EPM).
SHIRPA (SmithKline Beecham, Harwell, Imperial College, Royal London Hospital, phenotype assessment) was used as a primary screen to assess 1.5-year-old CAST mice for behavioral alterations compared with the non-transgenic littermate controls.
Notable differences occur when yap −/− phenotypes are compared with yap nl13/nl13 phenotypes.
As electrophysiological deficits often correlate with behavioral deficits, we examined whether the D36 mice might have more pronounced behavioral defects compared with KO mice.
Those girls have "significant cognitive and behavioral differences" as compared with older teenagers, she explained.
Behavioral differences between immature and adult animals exist at the level of primary cells, and passaged adult cells may dedifferentiate to a different phenotype when compared with the cells examined in this study.
No other developmental phenotype was observed compared with wild-type plants.
Additional studies from behavioral neurogenetics suggest that genes modulating dopamine neurotransmission mediate a variety of behavioral phenotypes associated with sensation-seeking [23] [27].
These behavioral phenotypes coincide with the onset of hippocampal synaptic dysfunction at Schaffer collateral-CA1 pathways in 5XFAD mice [29].
Repeated alcohol-withdrawal is known to induce long-lasting adaptations that underlie behavioral phenotypes associated with alcohol addiction.
These results indicate that behavioral phenotypes associated with Shank3 haploinsufficiency are largely strain-independent.
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