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Despite strong developmental abnormalities, very few behavioral phenotypes caused by loss of PHR protein function have been identified in any organism.
The close similarity of morphological and behavioral phenotypes caused by transgenic insertion into dusp27 and injection of morpholino against dusp27 demonstrates that loss of dusp27 expression produces a profound locomotor impairment.
Although our results with manipulations of the insulin pathway are satisfying as validation of our model system, they also suggest a potential mechanism for the adult behavioral phenotypes caused by developmental ethanol exposure.
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Thus, the liver phenotypes caused by an impaired Hippo pathway are strongly dependent on YAP.
Embryos injected with an nkx2.5 morpholino exhibited SHF phenotypes caused by compromised progenitor cell proliferation.
Although we can detect the role of iRhom in the development of the wing and eye under genetically sensitized conditions, the only prominent phenotype caused by loss of Drosophila iRhom is behavioral.
A histone mutant reproduces the phenotype caused by loss of histone-modifying factor Polycomb.
Both mutations disrupted Wnt/β-catenin pathway and failed to rescue CHD phenotype caused by Axin2 knockdown in zebrafish model.
Knockdown-resistant isoforms of Dync1i1 can partially rescue the phenotype caused by shRNA1-6 (Fig. S1C H).
The phenotype is a milder SBBS phenotype caused by haploinsufficiency.
The phenotype caused by Smc1 F584R is more surprising.
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