Our study copes with specific behavioral phenotypes but do not cover all possible phenotypes that could influence those we investigated here.
For the Fmr1 KO mouse there has been a slightly greater measure of success in identifying behavioral phenotypes, but the presence and magnitude of any observed effects varies widely across labs, behavioral paradigms, and across background strains.
Hatched cells indicate cases where we observed a significant behavioral phenotype, but the driver line used labeled a combination of cell types.
Behavioral phenotypes would also have been modified due to changes in social structure, reproduction and adaptation towards humans [1].
We found that this selection not only enriched for 3-HP tolerance phenotypes but also for wall adherence phenotypes (41% false positives).
This behavioral phenotype was also associated with an up-regulation of the MAPK signaling pathway and Egr-1 protein in the DG.
Whether ablation of adult neurogenesis causes a specific behavioral phenotype thus also depends on the actual task demands.
Our findings of more anxiety, attention and subtle social problems may indicate that the "preterm behavioral phenotype" may also apply in young adulthood.
We would also like to notice that our hypothesis isn't inherently much more outrageous than published ideas that certain behavioral phenotypes including but not limited to cognition, mood, sleep, personality, eating behavior, and even a variety of neuropsychiatric diseases [ 3- 5], as well as suicidal self-directed violence [ 33] and suicide rates [ 34], can be affected by microbes.
New methods for trait analysis combining information from different measures and including different aspects of functioning (such as the range of measures and assessments of the autism/BAP phenotype but also at other levels of investigation including other aspects of behavioral, cognitive styles, ability, and language) will be required.
