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Behavioral endpoints, such as swimming behavior, are amongst the most sensitive and ecologically relevant parameters to assess sublethal toxicity of neurotoxic chemicals [ 29].
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Abundance was a less sensitive endpoint than sublethal endpoints such as emergence.
Relevant clinical endpoints such as death or liver transplantation occur too infrequently in this orphan disease to be used as endpoints in phase 2 or 3 trials.
However, it remains unknown if they can predict more definitive endpoints, such as PCSM.
Phase II evaluation of such agents may instead focus on failure-time endpoints, such as time to disease progression.
Other endpoints such as "complete remission" (CR) are recognized in the treatment of oncological diseases, the endpoint "objective response rate" (ORR) is used e.g. for brain tumors.
The principal aim of this paper is to study the problems with general jointly varying endpoints such as with the periodic endpoints z 0 = z N + 1 or with the antiperiodic endpoints z 0 = − z N + 1.
Most of these studies investigated more general endpoints such as mortality, reproduction, growth, and food consumption over time, and less frequently examined molecular endpoints such as enzyme activity or gene expression.
Neither adverse effects on very sensitive functional endpoints such as photosynthesis measurements of algae and macrophytes nor adverse effects on structural endpoints such as abundance data and species composition were determined.
Time-to-event endpoints such as Progression-Free Survival have been recommended and led to new designs.
We also investigated other endpoints such as cardiovascular disease and peripheral arterial disease.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com