No death and no behavioral changes were observed within 24 h.
Our results show that most individuals made predictable daily crepuscular migrations between different locations and habitat types, although individual behavioral changes were observed for some individuals across time.
In both mice and guinea pigs, only after ip administration, minimal behavioral changes were observed transiently within 2 3 min after administration.
During therapy, no behavioral changes were observed that would indicate CNS toxicity, and after the therapy, organs were examined and no overt tissue damage was observed, i.e. no brain, heart or nephrotoxicity (data not shown).
C-fos antisense oligodeoxynucleotides (ASO) was used in our previous studies and the corresponding nociceptive behavioral changes were observed as a consequence of knocking down its protein product [24], [30], [31], [32], thus, it was employed in this study to shut down activated neurons.
Animals appeared lively throughout the study and no behavioral changes were observed between the treatment groups.
No evident behavioral changes were observed among treated animals compared with controls.
No behavioral changes were observed following exposure to PCB 52 in the present study.
We reasoned that if consistent behavioral changes were observed, then these data would support a neural function for yar.
The general signs and symptoms of toxicity such as death, changes in physical appearance or behavioral changes were observed for 24 h post administration of the extract.
Rats were removed from the study if subtle behavioral changes were observed for more than 2 consecutive days, as signs often accelerated quickly if rats were left on study.
