These findings suggest that the behavioral abnormalities observed in the PDGFR-β KO mice might be related to deficits in GABAergic neurotransmission (see below in detail).
There is a clear correlation between the number of genes that are orthologous to Hsa21 and the degree of behavioral abnormalities observed in mouse models (Table 1).
Our findings also suggest that loss of RIM1 in other brain regions or in multiple brain regions simultaneously may partially reproduce other behavioral abnormalities observed in RIM1 α−/− mice.
To test whether loss of RIM1 from the DG, select neurons of the cerebellum and arcuate nucleus of the hypothalamus in the fRIM1/POMC-cre+ mice was sufficient to induce any of the behavioral abnormalities observed in the RIM1 α−/− mice, we put the fRIM1/POMC-cre+ mice with sex-matched littermate controls through many of the same behavioral tasks.
Given the behavioral abnormalities observed in mice with their neuropeptides knocked out, including somatostatin (MGI 98326, impairment in motor learning) and neuropeptide Y (MGI 97374, seizure), the down-regulation of these neuropeptides may also contribute in part to the behavioral abnormalities of the Q129 mice.
Furthermore some of the behavioral abnormalities observed in the spontaneously hypertensive rat (SHR), a putative animal model of ADHD, are responsive to treatment with amphetamine and methylphenidate, although the effects of these stimulants and other dopaminergic drugs appear to be blunted in the SHR e.g. (Sagvolden, 1992; van den Buuse & de Jong, 1989; Yang, Amini, Swann, & Dafny, 2003).
However, there were no obvious behavioral abnormalities observed.
Behavioral and neuronal abnormalities observed in mice exhibiting a reduced expression of the dopamine transporter model important aspects of schizophrenia, addiction, and attentional disorders.
There were minor abnormalities observed in 94 examinations (23%%).
There are numerous field abnormalities observed in ocular fundus diseases.
Furthermore, the mechanistic relationship between abnormalities observed in the commonly used assays in experimental animals and the analogous symptoms in human patients is uncertain, especially for complex behavioral traits such as depression and anxiety.
