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Apparent behavioral abnormalities associated with decreased microglial cells point to CAR-T-cell-induced neurotoxicity.
These results corroborate the central role Homer2 plays in glutamatergic transmission and expand the network of proteins potentially contributing to the behavioral abnormalities associated with altered Homer2 expression.
Studies of human addiction and behavioral studies in rodent models of addiction have indicated that key behavioral abnormalities associated with addiction are extremely long lived [3].
More recently, "sandy" (sdy−/−) mice, spontaneously occurring dysbindin null mice, have been shown to exhibit a number of behavioral abnormalities associated with reductions in forebrain dopamine transmission [15], [16].
Another example is impaired neurotransmission that may be responsible for at least some of the behavioral abnormalities associated with aging [ 106].
The behavioral abnormalities associated with ASD occur prior to the onset of seizures in children with ASD and epilepsy [66,67].
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To quantify a known behavioral abnormality associated with neuropathy in mice, mechanical sensitivity was assessed in nondiabetic and diabetic ob/ob mice at 8, 9, 10, and 11 weeks of age.
Morphologic abnormalities associated with behavioral illness may be extremely subtle and difficult to detect.
This is the first demonstration that abnormalities associated with glial dysfunction can produce behavioral abnormalities consistent with mania.
Mental and behavioral disorders may also be a consequence of brain abnormalities associated with Usher syndrome [ 8].
These specific behavioral and neurological changes occur, not exclusively, owing to focal brain abnormalities associated with parasite cyst localization, but might be a result of pathological interactions between different brain areas.
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