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The behavior of these mutants received little attention, probably due to the current conviction that maintains that NOS2 does not participate in normal brain activity.
Although the ataxin-3 knockout models are apparently normal in baseline conditions, little is known about the behavior of these mutants under stress.
Identical behavior of these mutants in CD and fluorescence measurements as well as limited proteolysis assays ruled out the possibility of global conformational changes induced upon mutagenesis as the cause for the variations in the kinetic and binding parameters.
We then tested the localization behavior of these mutants.
Additionally, it has been shown that by mutating W102β, Y154β, and Y205β amino acids all to threonine, there is greater incorporation of both biotin- and nitrobenzofurazan-containing FPP analogues by the resulting mutant PFTases, although the kinetic behavior of these mutants was not investigated in detail.
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Taken together, these computational results provide a compelling rationale for understanding the behavior of these mutant PFTase variants and suggest that docking experiments should be useful in predicting the effects of mutations as this enzyme is further engineered.
We have provided some detailed methods for the use of C. elegans in the identification of mutants that are resistant to the effects of ethanol on locomotion and subsequent quantification of the behavior of those mutants.
We made additional mutants, and the behavior of these new mutants provides additional support for the model.
The intracellular trafficking behavior of these Tf mutants has been assessed by measuring their association with HeLa cells.
Here, we systematically investigate the behavior of these disease mutants in four different cell types: three not containing desmin or the related IF protein vimentin and the standard fibroblast line 3T3, which has an extensive vimentin system.
The presence of these arcs as well as the differential behavior of the mutants suggests that C. elegans controls more aspects of its motion than the stochastic rate of abrupt events.
More suggestions(16)
pattern of these mutants
behavior of these variants
behavior of these kids
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behavior of these columns
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behavior of these derivatives
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behavior of these opponents
behavior of these complexes
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