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The balance between the improved stability margins and acceptable behavior of the spindle is ensured by energy consumption measurements.
Furthermore, on the basis of the proposed model, the effect of steel and ceramic bearing materials on the thermo-elastic behavior of the spindle system was investigated.
A mechanical model of the spindle system is considering the mass eccentricity, and the dynamic behavior of the spindle in working conditions are simulated with the mathematical model.
To follow the behavior of the spindle we generated a NIH3T3 mouse fibroblast cell line that stably expresses α-tubulin fused to the mCherry [26] fluorescent protein (Figure 2 and Movie S1).
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After the geometric model and finite element model are conducted, the static, dynamic and thermodynamic behaviors of the spindle are optimized.
The static and dynamic characteristics as well as the operational behaviors of the spindle-bearing system under variable position preload and variable pressure preload are verified by experiments.
In this research, considering the effects of drawbar on the dynamic behavior of the milling motorized spindle-bearing system, a double-rotor model of spindle-drawbar-bearing assembly has been established by utilizing the whole transfer matrix method (WTMM) and a nonlinear rolling bearing dynamic model including the centrifugal force and gyroscopic effects.
Given the aberrant behavior of mitotic spindles in the first three cleavages prior to LR symmetry breaking (Bergmann et al., 2003), the it143 mutant could have slightly misplaced neighbors that could as well result in impaired LR symmetry breaking.
It is difficult to predict the behavior of trivalents on the spindle.
The results show that the drawbar is a sensitive part to affect the spindle dynamic behavior, and the effect of drawbar on the dynamic characteristics of the spindle system should be considered carefully.
The spatio-temporal assembly and dynamic behavior of mitotic spindles are critically important for proper alignment and segregation of the duplicated chromosomes, failure of which leads to cell death or genomic instability (for review [7]).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com