Sentence examples for behavior of the pathways from inspiring English sources

In order to investigate the behavior of the pathways, a dimension reduction procedure can be used that transforms expression values of all genes in a given module into one representative value for each sample.

In most situations, a change in one single nucleotide can affect the whole mechanism of a gene and consequently corrupt the behavior of the pathways involved, which could cause a disorder [ 10].

Modified adaptor and scaffold proteins can reroute signal traffic and adjust the response behavior of the pathway circuit.

The models are either linear and represent the stoichiometry and flux distribution in pathways or they are non-linear and account for the full kinetic behavior of the pathway, which is often significantly effected by regulatory signals.

This work indicates that the key quantity that determines the qualitative behavior of the pathway is the ratio of the constitutive to the ligand-induced rate of receptor degradation (CIR, constitutive-to-induced degradation ratio).

In some cases, the behavior of SPIA is closer to the GSEA, probably because both methods return a global pathway score (despite the fact that SPIA weights take into account the pathway structure, thus providing a more accurate description of the whole behavior of the pathway).

Furthermore, while mitochondrial deficiencies are often treated with metabolites to stimulate the enzyme activities, models will allow evaluation of the influences of metabolite treatments at the mitochondrial level, visualization of the dynamic behavior of the pathway and exploration of a hypothetical rationale of the treatment.

Because of the high impact of PIAS2 on the dynamic behavior of this pathway, the knockout of this gene in ESCs may facilitate differentiation of ESCs, while increased PIAS2 production may enhance the self-renewal of ESCs or benefit induction of a differentiated cell to the pluripotent state.

We then compare the behavior of those pathways in yeast and in the other organisms.

We suggest an abstract model concentrating on interfaces between the modules, which reproduces important behaviors of the pathway.

The observed bistability in expression of FLO11 can be directly related to the bistable behavior of the TOR pathway.