Sentence examples for behavior of the formulations from inspiring English sources
During in vitro dissolution testing, it was clear that the disintegration behavior of the formulations significantly influenced the rates of drug release.
In conclusion, adjusting dissolution testing conditions to match the behavior of the formulations in vitro with that in vivo is a useful approach in identifying a predictive method in development of in vitro in vivo correlation.
Regardless of the presence of RP, the rheological studies showed the pseudoplastic behavior of the formulations.
These mechanical parameters analyze the stress-strain behavior of the formulations, with the possibility to predict the effects on the stresses of the formulations encountered under physiological conditions [ 15], becoming an indispensable instrument in the study of drug delivery systems for choosing the most appropriate formulation.
Variability may be inherent to the dissolution behavior of the formulations or it may be an artifact of the dissolution method, e.g., coning, tablet landing and sticking to an off-center position under the paddle, capsule pellicle formation, spinning of the dosage unit, and a variety of other clearly noticeable dissolution anomalies (5).
To estimate the in vivo dispersion and dissolution behavior of the formulation, dissolution tests in several media simulating both the fasted and fed state stomach and small intestine were conducted, and the results from the in vitro dissolution tests were used as input function to describe the in vivo dissolution of the drug.
This would provide a clear understanding about the dilution behavior of the formulation under the in vivo conditions in stomach and intestine.
The study of the release profile provides essential information regarding the structure and the molecular behavior of the formulation, evidencing possible interactions between the drug and the polymer and their influence on the rate and mechanism of the drug release.
