It transforms transcriptional data of single genes into the behavior of gene groups, reflecting biological processes in cells (TF model, KEGG model and Subtilist model).
Although knockout or replacement of single genes has perceptible effects on behavior, these genes are part of larger networks whose functions remain poorly understood.
In all these species, the change of single genes has brought noticeable increases in life span.
While such complexity is to be expected in humans with their more complicated nervous systems, Schaffner believes that there may be a small number of single gene effects on behavior where these genes are highly homologous and strongly conserved hence, the usefulness of simple models like C. elegans combined with others for investigating basic mechanisms and psychiatric disorders.
Now we study the asymptotic behavior of the transcriptional regulatory network of yeast regarding information propagation under the influence of single gene perturbation.
We analyzed the general regulatory behavior of correlating gene expression samples of one tumor type and study, rather than analyzing the regulatory behavior of single patients.
In other words, the emphasis has shifted from associating a behavior to a single gene or its protein product simply because mutation of that gene disrupts that behavior to understanding how functional variability at the gene or protein level influences the dynamic coordination of neurons in systems that support a certain behavior.
Our biology is always part of our lives, but so are social inequality and privilege, history, diet, stress, popular culture, activity patterns, familial pressures, etc. Natural selection, one of the main drivers in evolutionary change, works on the whole body and behavior complex, not on single genes or even the genome itself.
The experimental testing of this single gene behavior is an important next step to confirm its biological relevance.
To this end, we took advantage of a well established model whereby exploratory or sedentary larval behaviors are under the control of a single gene [28] [30].
