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The semiconductor transistors that govern the behavior of our cell phones, our computers, our cars, and many other electronic devices are based on quantum-mechanical principles associated with the electronics that drive their computing capability.
We further analyzed how the adhesive behavior of our cell model systems could be modulated during QCM-D analysis.
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Nanotopography modulates the physiological behavior of cells and cell-cell interactions, but the manner of communication remains unclear.
The ECM has an active role in regulating the activity and behavior of cells, including cell shape, differentiation, proliferation and cell death.
Having established the overall behavior of our T6SS at the single-cell level using the relatively well-characterized TssB protein, we compared the properties of the other fusion proteins with TssB-mCh.
Beyond the effects of size exclusion on the invasive behavior of cells, our migration chip permitted the quantification of drastic differences in 2D and 3D migration speeds.
Such a community effect means that the behavior of a cell in our model simulation deeply depends on the context of surrounding cells.
In order to investigate global behaviors of our model with multi-target-cell and cell-to-cell transmissions, we simplified the input rate of uninfected target cells as a constant.
To observe the dynamic behaviors of cell-to-cell interactions, we cultured HUVECs on the collagen and denatured collagen films.
While the in vitro studies established that factors secreted into the media by G2B-10A cells are required for the enhanced clonogenic behavior of R2-T1AS cells, to our surprise, we found that PFA-treated, metabolically inert G2B-10A cells were able to increase tumor growth in vivo as efficiently as non-PFA-treated G2B-10A cells.
We therefore propose a four-factor heuristic which serves as a compact summary of our findings and can be used to predict the probable behavior of cell lines not in our collection.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com