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Notwithstanding the great progress made in the diagnosis and treatment of Müllerian adenosarcoma, its rarity and its heterogeneous behavior make difficult to set up well-defined therapeutic protocols.
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This kind of behavior makes it difficult to take social conservatives at their word when they insist that their opposition to, say, same-sex marriage is rooted respect for a longstanding institution instead of prejudice.
Our government's clandestine and not-so-clandestine but awfully objectionable behavior makes it difficult to support even a justifiable intervention.
One limitation is that the study used self-report measures rather than testing actual behavior, making it difficult to know whether participant reports of sexual behaviors were accurate.
However, different WF behaviors make it difficult to achieve the expected objective.
Large variations in methodologies (e.g., sample size and composition) and differences in the specificity of conceptualizations of both family adversity and externalizing behaviors make it difficult to integrate these findings and make cross-study comparisons.
However, it has been shown that under different conditions or different parts of the season, the same genotype may display characteristics of both isohydric and anisohydric behaviors, making it difficult to interpret results, and therefore, the term near iso/anisohydric is often used to describe different genotypes.
Research on health communication is complicated by myriad individual, organizational, and societal factors that influence health-related decisions and behaviors, making it difficult to control for secular trends (uncontrolled social and environmental influences) that affect health care and health promotion practices.
Yet consumer advocates and passengers who have been ordered off planes for seemingly petty infractions think some flight attendants abuse their power and that the broad language airlines use to define unruly behavior makes it difficult for passengers to know how to behave and, if necessary, defend themselves.
He's willing to make difficult decisions".
You ask people to make difficult decisions.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com