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Drugs used in the pharmacological treatment of ADHD, usually catecholamine agonists have been shown to reduce ADHD-like behavior in this model [ 19, 22- 25].
Provided that these impairments are, at least in part, relevant to negative symptoms, screening of novel compounds to normalize this behavior in this model may lead to the identification of new treatments for negative symptoms.
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However, the impairment of social behaviors in this model is resistant to both clozapine and haloperidol treatment.
Besides, the driver behavior used in this model is also close to real life.
The wide range of dynamical behavior seen in this model emphasizes the need to understand the impact of our model assumptions on the predicted dynamics.
The soil-pile interaction was simulated by adopting tangential and normal contact behavior in the model.
These values were tuned to ensure bistable switching behavior in the model.
Whether SAD1 behaves similarly to SAG1 is unknown, and thus SAD1 behavior in the model is purely speculative.
Furthermore, much work remains to determine the generalizability of the behavior in these model systems involving young tissue to behavior of cartilage in vivo in older humans.
The sequence of events and features of the behaviors observed in this model simulated those observed in human TLE.
More studies in fully back‐crossed (generation 10+) animals are required to better determine if indeed autism‐relevant behaviors exist in this model.
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