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Between reading recent news reports about altruistic behavior in rats and watching the slickly adorable antics of Remy the culinary rodent in this summer's animated blockbuster, "Ratatouille," I've had a change of heart.
Altered locomotor activity is one of the kindling and postkindling behavior in rats and mice [ 33, 34].
"They are reported to prevent dopamine production in monkey brains, to alter behavior in rats, and may even alter neuropsychological functioning in children," explains first author Tal Kenet, a faculty member at Harvard Medical School and Massachusetts General Hospital.
Data are mainly derived from animal models and a correct interpretation of findings from mouse testing has to be observed in the general context of a different social behavior in rats and mice [ 133].
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In a seminal translational paper, Rupprecht and colleagues reported that XBD173 decreased anxiety-like behaviors in rats and reduced the number and severity of panic attacks in humans [7].
Baclofen (beta- 4-chlorophenyl -GABA) is a GAbeta- 4-chlorophenyl -GABAhas beta- 4-chlorophenyl -GABAh acquisition of alcohol drinking beta- 4-chlorophenyl -GABAy alcohol istake in alcohol experienced rats.
They observed that a diffusion-limited PBTK model was necessary to characterize the toxicokinetic behavior of naphthalene in rats and mice.
For example, administration of 5-HT into the lateral but not the 3rd ventricle stimulated female sexual behavior in rats [ 266] and oxytocin administered into the lateral ventricle but not into the 3rd ventricle, suppressed lordosis [ 267].
BPA has also been found to abrogate sexual dimorphism in brain structure and behavior in rats (determined by estrogen signaling) (McCarthy 2008) and to disrupt cognition, social behaviors, and other aspects of brain function (Richter et al. 2007).
The restraint experience inhibited sexual behavior in rats treated with estradiol benzoate and CDB4124 and in rats treated with estradiol benzoate, CDB4124, and progesterone but not in rats given estradiol benzoate and progesterone without CDB4124.
PAR2 activation has been demonstrated to enhance TRPA1 agonist-evoked pain behavior in rats via PLC activation and subsequent PIP2 hydrolysis (Dai et al., 2007).
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