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Cancer cells and macrophages have bidirectional interactions through the exchange of soluble factors, a process that remarkably influences the behavior and phenotype of both cell populations.
Numerous studies have focused on characterizing the behavior and phenotype of CSCs.
However, the triple-negative subtype has been shown to be heterogeneous at the molecular level, including various subtypes with distinct clinical behavior and phenotype of drug sensitivity [ 32].
Collectively, these findings demonstrate the complex integration of extrinsic and intrinsic factors affecting the behavior and phenotype of breast cancer cells during the metastatic process.
(10) Controlling the behavior and phenotype of cells via the mechanical properties of their substrate in vivo may lead to the improvement of biomedical devices such as coronary stents and spine and retinal implants.
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Next, the process of gene editing alters the cellular genome, providing a novel way of controlling the behavior and phenotypes of cells being modified.
The neurobehavior ontology facilitates the systematic representation of behavior and behavioral phenotypes, thereby improving the unification and integration behavioral data in neuroscience research.
For example, the response "It changes a base in a DNA sequence which in turn alters the structures and behaviors or phenotype of the cell" would have earned a score of (2,0).
To examine the effect of CP2 administration on the development of behavior and memory phenotype in vivo, breeding heterozygous APP and PS1 mice were treated with 25 mg/kg/day CP2 in drinking water and progeny with all four genotypes were produced with the expected ratio (Fig. 1B).
Current clinical recommendations suggest that children with a normal birth weight but rapid weight gain in the first few months of life leading to extreme obesity should be tested for congenital leptin deficiency when they show impaired satiety, intense hyperphagia, and food-seeking behavior (see Clinical phenotype of patients with congenital leptin deficiency) [6],[7].
Since the authors have access to the lamin mutant mice and flies with specific perturbation of Ne components, figure (a) showing the circadian behavior phenotype of these animals will substantially strengthen the manuscript.
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