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This difference may reflect diverse biological behavior and pathways of tumor development among the older and the younger BRCA1 and BRCA2 patients, with impact also on prognosis and survival.
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As such, there is a substantial research effort seeking to discover new therapeutic regimens that maximize tumor killing while minimizing these normal tissue toxicities, based on understanding of the differences in the behaviors and pathways of healthy and neoplastic cells.
Based on the chromatographic retention behavior, fragmentation pathways of chemical components and the published literatures, a diagnostic ion filtering strategy with electrospray ionization quadrupole time-of-flight tandem mass spectrometry (HPLC-ESI-Q-TOF/MS) was established to identify the multiple bioactive constituents of GGFTT.
Therefore, these results suggest that osteoblastic cells arising from BM concentrate exhibit a normal behavior regarding paracrine pathways of osteoblast/osteoclast communication, which are essential for bone development and remodeling.
We conducted direct observation of 23 caregiver infant pairs for 130 hours and recorded wash-related behaviors to identify pathways of fecal oral transmission of bacteria among infants.
Our findings not only provide important new insights into understanding the differential DNA-damage response mediated by p53, but also produce quantitative new data for exploring the transitional behavior and regulation of p53 pathway dynamics for cell-fate control.
The fact that p53 fundamentally changes its dynamic mode, that is, switching from pulsing at low damage to monotonic increase at high damage, poses important new questions regarding the transitional behavior and regulation of p53 pathway dynamics.
It can also be used to study damped vibration behavior and stability of the biological pathways.
We can now measure brain structure and function on the same brains, and thus relate structural connections to brain function and behavior, 38 analyze developmental pathways of structural connections, 39 and relate structural connections to functional segregation, 40 among many other possibilities that were unavailable two decades ago.
Rat odors evoke immediate and intense defensive behaviors in laboratory mice, coupled with activation of brain pathways typical of defensive behavior and secretion of stress hormones.
A deeper understanding of the roles that these K-Channel markers play in other systems may provide important insights into the cellular properties, firing behavior, and state dynamics of vocal control pathways.
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