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Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are novel tools for the dissection of circuitry mediating behavior and neural function.
Repeated psychosocial stress in early-life has significant impact on both behavior and neural function which, together, increase vulnerability to depression.
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Thus, obesity-associated alterations of reward behaviors and neural functions are the result of both predisposing traits and secondary effects of repeated exposure to palatable diets and/or the obese state.
Schizophrenia is primarily a neurologic disorder externally observed as disturbed behavior, which is underlain by abnormal mental and neural functions (Lewis & Lieberman 2000).
This is *one* possible explanation that lends itself to an elegant model, but the mapping function between behavior and neural activity is complex, and many other schemes are possible.
The differences in behavior (and neural response) during different sessions with identical stimuli raised the possibility that behavior and neural responses might also change during a single session.
This latter finding concurs with previous research linking ventral striatal activity with the behavioral activation system (34) and with the dimensional approach to the study of psychiatric disorders advocated by the Research Domain Criteria (17), which focuses on dimensions of behavior and related neural circuitry function that cut across psychiatric diagnostic categories.
We use engineering approaches to understand and control neural function.
Frey, A. H., Feld, S. & Frey, B. Neural function and behavior: defining the relationship.
FreemoVR technology facilitates detailed investigations into neural function and behavior through the precise manipulation of sensorimotor feedback loops in unrestrained animals.
Norepinephrine-dependent modulation of long-term alterations in synaptic strength, gene transcription and other processes suggest a potentially critical role of this neurotransmitter system in experience-dependent alterations in neural function and behavior.
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