The resulting phenotypes include lethality or reduced lifespan, defects in axogenesis and neurite branching, altered synaptic morphology, axon and neuron degeneration, astrogliosis, defective fat metabolism, impaired motor behavior and cognitive deficits (11, 14).
The data presented here for motor function, anxiety-related behavior, and cognitive deficits are critically important to the future application and utility of this model in preclinical testing of AD-relevant therapeutics by: establishing baseline behavioral characteristics of this model; and providing valuable information helpful in appropriate study design.
Appropriate intervention at this stage could also prevent or delay the onset of psychosis and/or subsequent deterioration, i.e., social and instrumental disability, suicide, aggressive behavior, affective- and cognitive deficits.
Our results suggest how a postsynaptic GIT1 signaling complex plays a key role in controlling synaptic inhibition, by stabilizing GABAARs at the inhibitory synaptic site, and may be an important locus for altered animal behavior and psychiatric and cognitive deficits.
Increased parahippocampal ALFF was related to positive symptoms and cognitive deficit.
Together, these events trigger ultimate neuronal loss and cognitive deficit.
Partial knockdown of the fractalkine receptor also prevented microglial reactivity and cognitive deficits in obese mice.
Neuron loss and cognitive deficits were partially reduced.
Negative symptoms and cognitive deficits in schizophrenia are partially overlapping.
