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A valuable method to studying the mechanistic action of psychostimulants, such as MPD, on neuronal population is to record neuronal activity before and after administration of the psychostimulant in an intact, non-anesthetized, freely behaving subject through sensory-evoked field responses following sensory stimulation.
We believe it is less surprising that striatal, or any other, neurons predict time than that they predict time in a manner that agrees with the trial to trial variations in temporal judgments exhibited by a behaving subject.
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Combined with novel objective designs [47], [48], [49] and the ability to mechanically decouple the scanner from the laser with a hollow-core optical fiber [50], this could pave the way for a head-mounted scanner enabling microsecond three-dimensional random access in awake, behaving subjects.
However, whether dynamics in striatal activity can explain the perceptual performance of behaving subjects is unknown.
Extracellular neuronal recordings were made using standard electrophysiological methods in behaving subjects using fine wire tungsten microelectrodes (31 gage, Microprobe, Inc).
These results demonstrate that a read out of stimulus category from even modestly-sized ensembles of striatal neurons was in many cases sufficient to explain the pattern of duration judgments produced by behaving subjects.
Recording neuronal activity in behaving subjects has been instrumental in studying how information is represented and processed by the brain.
This paper describes an interesting but fairly standard set-up for neurophysiology data acquisition in behaving subjects.
However, no study to date has directly compared the speed of such "population clocks" with the duration judgments of the behaving subjects in which they are found.
To investigate the potential role of amygdala neurons in anxiety, we carried out multi-channel in vivo extracellular recordings in the BLA of freely behaving mice subjected to two ethologically-based tests of anxiety.
In 1950, Ginzburg, of the P. N. Lebedev Physical Institute in Moscow, and colleague Lev Landau formulated a theory that describes how superconductors behave when subjected to a magnetic field.
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