The "sexual revolution" began largely among college students in the 1950s, before the pill was available, and did not reach the mainstream until the late 1960s.
Her career began largely by chance when, one Sunday in the late 1890s, while reading in a cabin retreat her father had built for her, she was approached by three mountain children.
She said the H.I.V. epidemics in Asian countries began largely among drug users who inject themselves, prostitutes and gay men, but now "are fast moving into the general population".
That was when the search began, largely at the instigation of the writer Jack London, for a Great White Hope to erase what he called the "golden smile" from Jack's face.
Mr. Bernanke noted that global trade and financial imbalances had narrowed considerably since the crisis began, largely because the volume of international trade contracted by 20percentt from its peak before the crisis.
And thus Wilson's unexpected artistic Indian summer began, largely guided by his second wife, Melinda Ledbetter, a former car saleswoman he married in 1995 and with whom he's subsequently adopted five children.
The alternative comedians became part of the mainstream, made some money which they had to invest, had to decide whether to send their own children to public school, and began largely making the same decisions as the previous generation.
Although baseball bans the use of steroids and amphetamines, it had not tested for any performance-enhancing drugs until the steroid testing began, largely because the players union has been opposed to testing on the grounds that it infringes on players' privacy rights.
Enter Designer Fund, which began largely as the angel fund of Allen and Blumenfeld and has now raised outside capital to provide to companies in chunks of between $250,000 to $1 million.
