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Thermogravimetric analysis indicated that the as-prepared C2N-h2D crystal underwent a gradual weight loss from the beginning of the scan (Supplementary Fig. 4c).
The ones in group B were asked to make an inspiratory effort at the beginning of the scan, without previous coaching.
The volume of the myocardial chamber with 2 defects attached was 110 ml, giving an activity concentration of 10.54 MBq/ml at the beginning of the scan.
In group A, the patients were instructed to take several deep inspirations and expirations just before and during contrast infusion, followed by an inspiration just at the beginning of the scan.
For all human studies, the non-protein-bound fraction of [11C]GSK1034702 in arterial plasma (fP) was assessed by ultrafiltration for the blood sample taken at the beginning of the scan.
The optimal timing for the contrast-enhanced phases depends on the volume of contrast material, the administration rate and the individual's cardiac output these factors mandate a delay time between the start of the contrast introduction and the beginning of the scan [3].
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Sound loudness was individually adjusted at the beginning of the scanning.
This may have elicited curiosity at the beginning of the scanning session.
The 150 images within a given functional run were randomly chosen from a pool of 600 images created at the beginning of the scanning session.
The last AMPT dose was given 24 h after D3T0 (D3T24) and 1 h before the beginning of the scanning session (D3T25).
High-resolution (0.25-mm voxels) T1-weighted structural images were acquired with an MP-RAGE pulse sequence at the beginning of the scanning session.
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