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Let us begin with the down side.
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Carcinomas constitute almost 90% of cancers and upon oncogenic transformation, the process of tissue invasion and metastasis begins with the down-regulation of E-cadherin.
Although EMT is described as a multi-step process that begins with the down-regulation of E-cadherin, it needs to be recognized that the regulation of E-cadherin is separate from that of mesenchymal proteins.
To perform a row, begin with the dumbbells down at your side.
Begin with the treat held down at your side.
Most of the time a dressage test will begin with the horse trotting down the center line.
Then the ventrum was examined beginning with the ears, down the face, then down the left side of the body, followed by the right side of the body.
To begin with, the car was stripped down to the bare frame.
To begin with, the emotional ups and downs of getting hung up on one person are so draining that they could almost make you want to give up on dating entirely.
Because the number was relatively high to begin with, the growth rate inevitably slowed down.
If using a patterned or colored napkin, begin with the pattern or colored side down.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com