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The findings from this study provide a previously unreported baseline from which the potential impact of changes to service provision and/or treatment practice can begin to be evaluated.
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Likewise, strategies have begun to be evaluated that would allow rationalization of efforts and resources to achieve screening of the maximum number of individuals, with high quality standards, but without completely overloading the healthcare system.
What the ramifications of this to the tumour microenvironment is only beginning to be evaluated.
These observations have led to huge efforts to develop inhibitors that suppress the PI3K and mTOR pathways that are beginning to be evaluated in clinical trials (Engelman, 2009).
Several approaches have now been developed and are beginning to be evaluated for combating mental illness stigma among health care providers [ 36, 43, 44, 46, 47].
Novel processes, including inflammation and genetically based pathways, are beginning to be evaluated, along with tests for preclinical disease, with the hope of accelerating this understanding.
Many of these novel biomarkers are only now beginning to be evaluated in clinical settings, however, and none has as yet been qualified as a biomarker that can predict clinical outcomes.
However, the current model of care for hospitalized older adults plays an important role as a risk factor for in-hospital functional deterioration and has only recently begun to be evaluated [ 4, 20].
While there have been many studies examining the use of computer and Internet-based interventions promoting healthy diet and exercise, 3 7 social media offers a new group of tools whose efficacy as an intervention for lifestyle modifications is just beginning to be evaluated.
In sepsis, microcirculatory alterations are more complex and, as new techniques for monitoring this difficult-to-access "organ" become available, the extent of microvascular dysfunction and the role it may have in promoting sepsis-related organ dysfunction are only now beginning to be evaluated.
Therefore, by demonstrating novel antileishmanial activity for a drug already in clinical use for another indication, a candidate drug or perhaps combinations of drugs can begin to be effectively repurposed by being evaluated in phase II clinical trials and bypassing approximately 40% of the overall cost that it takes to bring a novel drug to market [ 47].
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