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The period in which she found herself as a TV star was one that began with a setback.
Glyndebourne's 2016 season began with a setback: the absence of music director Robin Ticciati, forced to withdraw from the season opener, a revival of Wagner's Die Meistersinger von Nürnberg.
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A promising move to Boston in 1882 began with a jolting setback: the death of her third husband, Asa Gilbert Eddy, on whose support she had relied since their marriage in 1877.
For him, the journey of a thousand setbacks began with a single misstep in Houston, more than three years ago.
But Mount St. Mary's couldn't extend that momentum and lost three straight contests -- beginning with a 10-7 setbatk at Robert Morris, which finished sixth in the NEC.
It began with a sneer.
It began with a cough.
It began with an earthquake.
As Paul Wolfowitz, the deputy defence secretary, told Congress, all the best arms programmes began with one setback after another.
Eighteen sixty-two began with more setbacks, as the two leading teams in Newark, N.J., came close to suspending play because so many of their men had enlisted in state regiments.
WHAT began as a setback for President Álvaro Uribe is starting to look like a partly self-inflicted rout.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com