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However, these data highlight the need to better evaluate the potential benefit or harm of REBOA before widespread clinical implementation.
Before widespread clinical implementation, CPRs should undergo three stages of development: (i) Derivation: factors with predictive power are identified to develop the CPR; (ii) Validation: The CPR is tested in a new population for reliability and accuracy; and (iii) Impact analysis: The impact of the rule may be examined in terms of physician behavior, patient outcomes, or costs [ 7].
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The widespread clinical implementation of gene therapy requires the ability to stably integrate genetic information through gene transfer vectors in a safe, effective, and economical manner.
This review provides an overview of the application of texture analysis with different imaging modalities, CT, MRI, and PET, to date and describes the technical challenges that have limited its widespread clinical implementation so far.
What are the flaws and potential concerns impeding its widespread clinical implementation?
However, challenges exist to widespread clinical implementation of genomic medicine, a prerequisite for developing evidence of its real-world utility.
Despite all the data available and widespread clinical implementation, PCT has shown limited value for risk stratification and prognostication.
Despite its high prognostic value, widespread clinical implementation of I-meta-iodobenzylguanidine (MIBG) myocardial scintigraphy is hampered by a lack of validation and standardization.
Although technological improvements are essential for the widespread clinical implementation of exome sequencing, we have no doubt that these will be developed in the coming years.
With further widespread clinical implementation of high-resolution human genome analysis, submicroscopic genomic duplications and deletions will probably be identified at an increasing rate.
Before widespread clinical use of this material, its biocompatibility has to be thoroughly assessed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com