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The pathogenetic significance of these phenomena was not apparent before we demonstrated suppression of diabetes-mediated organ damage by Cu II -selective Cu II -selective, 12, 42, 43].
The transduction of osteoclasts had been extremely difficult before we demonstrated that adenovirus vector-mediated gene delivery system can be successfully used to transduce foreign genes into osteoclasts both in vitro and in vivo (23, 24).
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Before we demonstrate this theorem we needs the following lemma.
Before we demonstrate how propensity score methods address the issue of selection bias, we need to introduce a conceptual distinction between the average treatment effect (ATE) and the average treatment effect on the treated (ATT; Imbens 2004).
Although we expect that this will bring us numerous benefits, there are a number of technical issues to be resolved before we demonstrate the practical use of coordinated manipulation with human-like dexterity.
Before we demonstrate our profile biomarker approach's advantages.
Besides showing the effectiveness of siRNA against EHV-1 when applied before infection, we demonstrated that siRNA application to mice after challenge infection was effective in reducing clinical symptoms and virus replication in the lungs of treated animals.
Like other authors before us, we demonstrated a significant correlation between NT-proBNP levels on one hand and age and decreased left ventricular ejection fraction on the other hand.
We demonstrated before, that no single round transcription takes place with core enzyme alone (data not shown).
Since we demonstrated before that the thiopeptides inhibit the transcriptional activity and the expression of FoxM1 [18], [18] and here we showed that they also act as proteasome inhibitors (Fig. 1), we decided to test the notion that other known proteasome inhibitors may inhibit FoxM1 as well.
We demonstrated before that taking into account urinary output improved the diagnostic performance of RIFLE [ 37].
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