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Children with CD recorded before their entry date were considered to have prevalent disease and were thus excluded.
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Also 83,824 (25.6 %) patients were excluded who either were prescribed antidepressant medication more than 36 months before the recorded date of depression diagnosis, before their study entry date, or before the age of 20.
We excluded patients who had been prescribed one or more prescriptions in the past 180 days before their study entry date.
Individuals who died before their study entry date (1 January 1995 31 March 2003) were identified by linking to the NLCHI mortality system and the Statistics Canada Annual Mortality Data Files and were excluded.
We excluded patients without a valid postcode related Townsend deprivation score, and existing users of anticoagulants by excluding those prescribed anticoagulants in the 180 days before their study entry date.
Of these, 2041 (0.1%) had a missing Townsend score and 15 022 (1.1%) had at least one prescription for anticoagulants in the 180 days before their study entry date, leaving 1 358 231 eligible patients for analysis.
Their study entry date was their first valid serum creatinine result after the eligibility criteria were met.
People who developed colorectal carcinoma or died before their individual study entry date were excluded from analyses in both groups.
For patients with less than one year of registration with the general practice at the time of their first prescription, we moved their cohort entry date forward in time to allow a minimum one year medical history before the cohort entry.
For patients who had started an anticoagulant after their initial entry date, we assigned an index entry date that was the date of their first prescription of the anticoagulant during the study period.
Patients with a recorded diagnosis of depression before the study entry date and those prescribed antidepressants before this date, before their date of registration with the practice, before the age of 20 or more than 36 months before their first recorded diagnosis of depression were excluded.
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