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The stool sample was collected on the same day or a day before the study visit.
Patients were not permitted to take any acetaminophen on the day before the study visit.
Diet assessments in each participant are made the day before the study visit.
The researcher corresponded with participants during the recruitment process but had never met them in person before the study visit.
Next, this analysis assessed symptom-based efficacy based on the worse rectal bleeding and stool frequency Mayo subscores of 3 days before the study visit.
During the year before the study visit, 42.3% (95% CI 40.8% to 43.9%) of all 3920 enrolled patients had undergone a dental examination.
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Before starting the study (visit 1), a physician took demographic data, diseases, and "risk factors" for skin irritations, such as excessive sports and excessive sweating, overwashing of the intimate area, urine and/or fecal incontinence, or tight clothing.
Subjects consumed all regular medications with water in the morning before the study visits, including their prescribed prednisolone dose.
Subjects were asked to refrain from alcohol and exercise for 2 days before the study visits, and no subject smoked during study visits.
A probe solution containing 7.5 g lactulose and 2 g mannitol in approximately 100 ml of water was administered orally in the clinic on day 0 and in the evening before the study visits on days 7, 14, and 21.
Patients have to be instructed that for the duration of the study they must not take any pain relief medication other than paracetamol (which will be used as rescue medication and can be taken during the study except 48 hours before the study visits).
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