All patients had been diagnosed with T2DM within 5 months before the study enrollment and none of them have received drug treatment for T2DM.
Covariates known at the time of inclusion were the parasitaemia, the type of treatment, the gender, the patient's age, the bodyweight (kg), a previous treatment before the study enrollment, the haematocrit and the baseline body temperature.
Included were subjects who underwent kidney biopsy during the study enrollment period, before they were started on immunosuppressive treatment for their LN.
Finally, we evaluated the impact of the variable indicating "time at risk" (i.e., duration of residence in the facility before study enrollment) in the multivariable model.
The median number of days in the ICU before study enrollment was 1 (25 75% IQR 1 2), and the median day of AKI development was day 1 after study enrollment (25 75% IQR 1 3).
Stratification was performed with the following variables: duration of residence in the facility before study enrollment (divided into quartiles) and hospitalization in the prior year.
Health care utilization was measured by total number of outpatient encounters with health care providers and inpatient days at the UW Medical Center and affiliated hospitals and clinics during a 2-year period that included the 12 months before study enrollment and the 12-month intervention period.
Among the 974 patients for whom reasons for discontinuation of the prior biologic before study enrollment were available, the reasons were: primary inefficacy (26.6%, n = 259), loss of efficacy (secondary inefficacy) (46.5%, n = 453), safety and tolerability (22.0%, n = 214), other unspecified reasons (5.6%, n = 55), and achieving remission or experiencing a major improvement (0.5%, n = 5).
If, as in the general population, the women in ACCORD are found to have a higher heart disease mortality rate than the men, it seems unlikely that failure to recognize clinically silent heart disease in the years before study enrollment could be a major cause.
Potential study subjects were excluded if they smoked more than two packs of cigarettes in the year before study enrollment.
Among only those patients hospitalized, the mean duration of hospitalization was 51.2 days in the 6 months before study enrollment and 71.0 days in the 12 months before study enrollment.
