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All patients signed written informed consent prior to inclusion and passed a screening examination including physical and ophthalmological examination during the 10 days before the study day.
Preferences for the test meal foods assessed before the study day, baseline (pre-drink) appetite ratings, BMI, dietary restraint, and eating disinhibition all failed to account significantly for variance in test meal intake.
Alcohol and caffeine-containing beverages were avoided for at least 24 h before the study day.
The mask was worn outdoors and during much of the time indoors for 24 hours before the study day as well as the entire study day itself.
Before the study day, subjects were asked to avoid foodstuffs naturally enriched in C for 48 h and refrain from strenuous exercise and alcohol for 24 h before the study.
On the evening before the study day, subjects consumed a standard meal (32 ± 2 kJ kg−1 body weight, consisting of 55 Energy% (En%), carbohydrate, 25 En% protein and 30 En% fat).
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Data were collected about demographics, comorbid conditions, admission source, laboratory results, and therapies within a 48-h window around the study day (9 00 am before to 9 00 am after the study day).
The type 2 diabetes women did not take their usual medication (except insulin) the evening before and on the morning of the study day.
Quantitative diaries capturing state sleep-related and psychosocial variables were filled out on the evening before each study day as well as 45 min post-awakening on the study day.
If sensor failure occurred before the third study day (the CRC visit) the sensor was replaced.
One week before the last study day, the diet was expanded, with a normal breakfast to achieve a caloric intake of 1000 kcal/day.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com