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Eight patients died before the second cCT scan.
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The timing of the second cCT scan is also not standardized.
25 out of 445 patients required intervention, according to the results of the second cCT.
55 patients with progression or new findings on the second cCT had no clinical signs of neurological deterioration.
The variables of interest were demographics, Glasgow coma scale, Glasgow outcome scale, the injury severity score (ISS), clinical signs for cerebral deterioration between the first and the second cCT scan, results of the cCT scans, and a change in therapy due to the results of the cCT scan.
Main outcome variables were progression of intracranial injury, new findings in the second cCT scan, and whether these findings resulted in a change of therapeutic management.
In those patients without clinical signs of neurological deterioration (n = 119) there were 55 patients (46%) with progression or new findings on the second cCT.
This is the first CCT finite-mixture model, and it is named the Multi-Culture GCM (MC-GCM).
Patients with neurosurgical interventions after the first cCT scan were excluded from the analysis.
31 patients (21%) had clinical signs of neurological deterioration (change in pupil status, n = 30, and seizures, n = 1) between cCT 1 and cCT 2. None of the patients with intracranial pressure monitoring (n = 12) had an increasing intracranial pressure which would have triggered a cCT earlier than 6 hours after the first cCT.
Three patients had a neurosurgical intervention immediately after the first cCT and were therefore excluded from the analysis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com