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Subjects had to abstain from caffeine intake 2 days before the first dosing and until the end of the study and cocoa and chocolate were not allowed 24 h before the dosing day.
Electrophysiological measurements were conducted 1 day before the first dosing and on day 6 after the final dosing.
The patient has had a severe blood loss (≥ 400 mL, e.g., blood donation) within 2 months before the first dosing of the study medication.
In addition, all AEs that started before the first dosing but that worsened in severity at or after the first dose were considered to be TEAEs.
Blood samples for assessment of pharmacokinetic parameters were taken before the first dosing, at frequent intervals within the first 24 h after the first dosing (at intervals of 0.25 2 h) and immediately before subsequent doses (Visits 3 and 4, and Visits 10 and 11).
Subjects attended a screening visit less than 28 days before the first dosing of the study drug in period 1. Upon arrival at the unit in period 1, subjects were randomized 1 1 (using a computer-generated list) to receive a single subcutaneous injection of 10 μg/kg body weight of EP2006 or originator filgrastim.
Similar(53)
Vitamin B12 injections (1000 μg intramuscularly) should also be started one week before the first dose of chemotherapy.
Patients received irinotecan at 40 mg/m(2) daily for 3 days, beginning just before the first dose of gemcitabine.
Poonawalla estimates that it will take a year, at the very minimum, before the first doses can reach the market.
Each 8-week cycle included paclitaxel 90 mg/m2 provided intravenously weekly for 6 weeks, followed by 2 weeks off therapy and oral estramustine 280 mg twice daily for 3 days beginning 24 hours before the first dose of paclitaxel.
Arterial blood gas, static lung compliance, and chest radiograph are obtained before the first dose of study drug and immediately before organ procurement for assessment of the primary and secondary study endpoints.
More suggestions(16)
before the initial dosing
before the first obstacle
before the first match
before the first kickoff
before the first fault
before the first world
before the first performance
before the first operation
before the first control
before the first rehearsal
before the first anthrax
before the first visit
before the first page
before the second dosing
before the first deal
before the first ad
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