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Most directors simply give up before the challenge of the second part, Mr Stein says, and it is not hard to see why.
As a candidate for the National Action Party, Fox overcame the legendary PRI electoral machine with bull-headed determination, but once in power he seemed to shrink before the challenge of dismantling the nuts and bolts of the regime.
The old Beaverbrook organisation had been floundering for years; the Daily Express was wilting before the challenge of David English's rejuvenated Mail (which had picked up a few tips from Wintour's Standard) and the Sunday Express was looking stale and stuck in an ancient rut.
Penetration of melanoma cells could be significantly decreased when CXCL9 was preincubated with anti-CXCL9 antibody or when the melanoma cells were treated with anti-CXCR3 antibody for 1 h before the challenge of the EC monolayer.
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We will confront the hard issues -- threats to our national security, threats to our health and retirement security -- before the challenges of our time become crises for our children.
"Ready-prepared broth can now be found in most major supermarkets," says Vicki. "Even gyms and fitness centres are now serving broth as a suitable winter alternative to cold juices that may contain antioxidants but do little to replenish a hungry post-workout body before the challenges of the day ahead".
The group finds, as others have before them, that the challenge of doubling global food production in coming decades can probably be met, albeit with considerable difficulty.
It was a straightforward victory for the German, with McLaren's Jenson Button climbing up from fourth to second before fending off the challenge of Vettel's team-mate Mark Webber.
Sporting are unlikely to receive any similar let-offs when they play an Athletic Bilbao side who knocked out Manchester United before seeing off the challenge of German outfit Schalke.
But Chadli equalised after escaping his marker and latching onto Dier's ball before holding off the challenge of Maya Yoshida to side-foot across Kelvin Davis from close range to seal a point.
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