Allowing the cost per dose for strategy B to vary, the figure illustrates that a large cost difference per dose of >33.3% would be required before the 3-dose schedule would become less costly; this occurs at the point at which the dash dotted line crosses the dashed line.
Specifically, statistical significance had to be observed at the 60 mg dose before the 30 mg dose could be considered.
Clinical laboratory tests (haematology and blood chemistries) were performed at baseline, before the day-8 dose of each cycle, within 4 days before the start of subsequent cycles, and on day 21 of cycle 8.
The mean VGB concentration (±SD) for all VGB-treated patients (except Patient 6) increased from 1.34 ± 0.84 μmol l−1 before the first dose to 2.57 ± 1.59 μmol l−1 after the first dose and 4.12 ± 2.32 μmol l−1 after the third dose.
In case of such complications women were also administered steroids before the delivery (4 doses of 6 mg dexamethasone during 48 hours between 24 and 34 weeks of gestation).
Mean GABA concentration (±SD) increased steadily from 0.27 ± 0.11 μmol l−1 before the first dose to 0.61 ± 0.30 μmol l−1 for the period between the third and fourth doses, although this increase and the increases for each inter-dose period did not reach statistical significance (Student's paired t test; P > 0.05).
The largest increase in GABA over the course of three doses was seen in Patient 10, catheter A, from 0.43 μmol l−1 before the first dose to 1.21 μmol l−1 after the third dose.
Seroprotection rates assessed by HI assay increased from 27% (18 60 years) and 54% (>60 years) immediately before the 7.5 μg booster dose to 83% and 92%, respectively, 3 weeks following the booster dose.
> -wrap-foot> Seven months after the primary vaccination series and just before the 11-month booster dose, the pneumococcal serotype-specific serum IgG concentrations had declined to low levels in both groups.
The remaining patients formed the sparse sampling group, from whom one sample was taken in each of at least two of the following four time intervals: 0 to 1 hour (after the first dose but before the second dose); 1 to 3 hours (after the second dose but before the third dose); 3 to 8 hours (after the third dose); and 8 to 12 hours.
