Participants were not asked to fast before study visits, and their postprandial status was not recorded.
We averaged PM2.5 over 48 hr before study visits and analyzed 202 single nucleotide polymorphisms (SNPs) in 25 genes.
We also averaged the 24-hr predictions to form estimates for the 4-week average during the 5 8 weeks before the study visit and the 4-week average during the 9 12 weeks before the study visit, which are components of the 8- and 12-week averages, to use as a sensitivity analysis.
Human milk was collected using an Avent ISISTM breast pump (Philips Avent, London, UK) [ 5] at mid-afternoon from each breastfeeding mother the day before study visit weeks 4, 8, and 12.
Fever (65.9%; 60/91 episodes) and ear pain (57.1%; 52/91 episodes) were the most common symptoms reported before the study visit and also during the study visit (49.5%; 45/91 episodes and 56%; 51/91 episodes, for fever and ear pain respectively).
Subjects with type 2 diabetes discontinued oral diabetes medications and long-acting insulin 5 days before a study visit, and therapy with short-acting insulin was initiated to temporarily control hyperglycemia, if needed.
Predialysis blood pressures taken as part of routine care were recorded for the previous three hemodialysis sessions before the study visit, and the mean systolic blood pressure was used as the primary predictor.
Before study visit, most patients (436/525; 83%) had visited their PCP (84.8% and 81.3%; intervention and control groups respectively), with a mean of 3.4 ± 2.70 visits in the previous 3 months.
LMS-QoL, FIS and BDI-SF were completed by patients at home within 7 days before study visit or at the clinic just prior to the visit.
Those who were not prescribed DMARDs before study visit 4 (n = 8) or who had incomplete data records (n = 28) were excluded from analysis.
