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The clinical characteristics before study start in the original study and in the replication study are listed in Table 1 and 2, respectively.
In 18 patients (14%) rheumatoid arthritis was diagnosed within 3 years before study start, in 30 patients (24%) between 4 and 10 years, and in 28 patients (22%) disease was diagnosed more than 10 years ago.
The patients continued on their adjusted medication and their usual fluid and food intake until the day before study start in order to study them in a clinically and physiologically stable phase, and also to minimize the discomforts of taking part in a study.
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The clinical characteristics before study start are summarized in Table 1 and 2. In the original study, we selected 77 case subjects and 152 healthy control subjects from among 1803 Japanese male employees [ 5].
Continuous behaviour therapy (ongoing before study start) was applied in 10 (N = 6.3%) patients, and 2 (1.3%) patients received occupational therapy.
Patients with primary codes from the Tenth Revision of the International Classification of Diseases (ICD-10) that were compatible with COPD (J44.0, J44.8, J44.8 or J44.9) from hospital admission up to five years before study start were included in the COPD-ICU group.
Approval from the ethical committees or boards of the following institutions was obtained before the WHO pilot registry study started in each respective country: the WHO, Ghana Health Service, Moi Teaching and Referral Hospital, Makerere University Faculty of Medicine, and the Uganda National Council for Science and Technology.
The study started in 2010 before the beginning of the intervention with a baseline data collection.
Although our study started in 2011, before the recent 'Berlin definition for ARDS', we found that 100%% patients would have fulfilled the criteria of the new definition.
The study started in 2007.
The exclusion criteria were former use of RCA within 72 h before the study start, concomitant participation in another clinical trial, and previous participation in the same study.
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