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23 Briefly, adults or skeletally mature adolescents (≥12 years of age) weighing ≥45 kg with radiologic evidence of ≥1 mature long bone, histologically confirmed GCTB, radiographically measurable active disease within 1 year before study enrollment, and Karnofsky performance status ≥50 % were enrolled.
Borderline significant associations existed between carriage of such organisms and duration of residence in the long-term care facility before study enrollment and prior metronidazole use.
Among only those patients hospitalized, the mean duration of hospitalization was 51.2 days in the 6 months before study enrollment and 71.0 days in the 12 months before study enrollment.
Four of 12 subjects were atopic (positive skin prick test), four were unable/unwilling to withdraw from antihistamine use but had previously tested positive for allergies before study enrollment, and four had invalid skin prick test results (negative histamine result or positive saline result) but reported allergic symptoms.
Health care utilization was measured by total number of outpatient encounters with health care providers and inpatient days at the UW Medical Center and affiliated hospitals and clinics during a 2-year period that included the 12 months before study enrollment and the 12-month intervention period.
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Most patients were naïve to any treatment before study enrollment (Table 1), and analgesic use in China is low overall compared with the United States [ 36].
Stratification was performed with the following variables: duration of residence in the facility before study enrollment (divided into quartiles) and hospitalization in the prior year.
All patients had been diagnosed with T2DM within 5 months before the study enrollment and none of them have received drug treatment for T2DM.
After informed consent, but before study enrollment, subjects underwent a history and physical including electrocardiogram (ECG), spirometry, and standard laboratory evaluation.
The median duration of diabetes and ulcer before study enrollment was 10.6 years (range 5 to 25 years) and 6.5 months (range 3 to 24 months).
Before study enrollment, the children's parents read and signed an informed consent form.
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