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Twenty-one women were lost to follow-up before study completion and therefore are only included in the demographic analyses.
Two women were lost to follow-up before study completion and are therefore only included in the demographic analyses.
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Of 287 patients screened, 169 were recruited and 36 withdrew before study completion.
Five of these did not complete the study: three were never discharged during the study period and one died before study completion.
Biased selection for publication may affect research dissemination over the whole process from before study completion, to presentation of findings at conferences, manuscript submission to journals, and formal publication in journals.
In total, 73 (25.9%) olmesartan-treated patients and 64 (22.5%) placebo-treated patients were discontinued before study completion due to adverse events (ESM Table 1).
A larger proportion of patients in the febuxostat arms than in the allopurinol arm discontinued the interventions before study completion: 88 (34%) with febuxostat 80 mg/day, 98 (39%) with febuxostat 120 mg/day, and 66 (26%) with allopurinol.
Only 1 in 22 of such studies register their primary outcomes before study completion.
Sixty-four subjects in the colesevelam group withdrew before study completion, relative to 90 subjects in the placebo group.
A total of 49 (11%) subjects discontinued before study completion, with a similar proportion discontinuing across treatment groups (Supplementary Fig. 2).
Of the remaining studies, the published primary outcome or aim was not registered before study completion, or not registered at all.
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