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The remainder had received their last BoNT/A injection a median 15.7 weeks (range 12 171 weeks) before start of study.
All subjects were told to have their meals at least 2 h before start of study.
Animals were group-housed with unlimited access to food and water and acclimatized for 2 weeks before start of study.
Data presented as the mean ± standard error of the mean, and represent values of the day before start of study.
Limitations of the earlier publications were brought forward, among which were short follow-up, failure to correct for body mass index, the impossibility of breaking down the risk of cancer in general to a tumour-specific risk, the inability to consider prior use of insulin before start of study, low numbers of patients using a specified insulin and the absence of dose analyses [ 32].
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All patients were informed about the investigational nature of the study according to institutional and regional guidelines, and subsequently gave informed consent before start of the study.
The Institutional Review Board of the Academic Medical Center approved the study protocol, and informed consent was obtained from all patients or their legal representatives before start of the study.
The study was approved by the Medical Ethics Committee of the Academic Medical Center, Amsterdam, The Netherlands, and all patients provided informed consent before start of the study.
Coffee, tea, cocoa or other methylxanthine-containing foods or beverages, and tobacco were not allowed for at least 12 h before start of the study.
Parents are excluded when their child reaches the age of 13 before start of the study.
One patient had been hospitalized within 3 months before start of this study.
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before start of conditioning
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before release of study
before start of follow-up
before testing of study
before start of combination
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before start of trastuzumab
before start of school
before evaluation of study
before administration of study
before start of raltegravir
before start of supplementation
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