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Before routine use of engineered cartilage grafts in the clinic, the safety and efficacy of these therapies need to be validated in prospective human clinical trials.
These studies were conducted before routine use of coronary artery stenting and, as warfarin is not considered adequate for preserving stent patency compared to thienopyridine agents [45], [46], [47], its use has lost ground to competing antiplatelet and antithrombin regimens.
This will need to be expanded significantly before routine use of WGS data becomes a reality.
Prior to 1990, before routine use of computed tomography (CT) scanners, EBRT was delivered using 2D treatment planning.
Despite promising short- and midterm results from clinical studies, further basic science and translational studies are desirable before routine use of ACNs in clinical practice.
This is a pilot study, and further careful study is required before routine use of call centre pre-screening, although the challenges of statistical proof of superiority or non-inferiority for health services delivery are substantial.
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Patients were treated by mastectomy well before the routine use of adjuvant therapy.
The displacement by muscle forces across the fracture site and associated ligamentous injury has been shown to be a source of significant morbidity in the past, especially before the routine use of contoured compression plates for treatment [10, 11].
However, many trials were undertaken before the routine use of P2Y12 inhibitors.
However, several methodological issues must be addressed before the routine use of serum biomarkers can be implemented.
Therefore, before a routine use of this image approach is used in daily practise, more studies from different centres should be performed.
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