Exact(9)
Increased renal protein leakage was indicated from end-point urine samples which showed that the protein/creatinin excretion ratio (µg/µg) in apoE−/− mice on HFC alone for 10 weeks of 0.15 (pooled data) was higher than the ratio of 0.07±0.04 found in mice on NC, and before pump implant (see figure 4).
Subjects will be replaced if they withdraw before pump implantation has taken place.
Mice were injected with SA3N (0 120 μg/kg) before pump implantation.
Imaging was performed before pump insertion (at day −14), then after 14 and 28 days of infusion (Fig. 3).
Furthermore, those participating were different to those considered suitable for pumps by NICE, which advises patients use analogue-based MDI before pump therapy.
Serial echocardiography (Visualsonic Vevo 770™, 30 MHz linear signal transducer) was performed under isoflurane/oxygen anaesthesia before pump implantation (Day 0), at Days 14 and 28.
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