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They need to be piloted before large scale implementation to check for unforeseen difficulties in use and adverse consequences but they do fill an important gap.
Finally, the importance of evaluating new methods must be emphasized, as well as re-evaluating established methods by clinical research in our own population before large scale implementation (in contrast to the hazards of direct implementation from animal and in vitro experiments).
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To optimize these methods, certain problems need to be addressed before large-scale implementation.
Stock enhancement is an attractive option for the management of fisheries but needs to be carefully evaluated before large-scale implementation.
In addition, involvement of the target group may imply that the guideline is first being tested in practice before large-scale implementation takes place [ 59].
The immediate priority is a field trial aimed at addressing uncertainties regarding model parameters and determining any practical issues that would need to be considered more carefully before large-scale implementation of the strategy can take place.
It is therefore essential that its fate and transport in the environment be assessed before its large scale implementation.
It is therefore important that investigations be performed in other areas in South America urgently where P. falciparum is endemic to determine the presence and geographical spread of parasites lacking the pfhrp2 and pfhrp3 genes before the large scale implementation of malaria RDTs in this area.
Additional and robust evidence is required [ 18, 22] before realizing a large scale implementation of an end-of-life care pathway.
Given that Apple sold 250m iPhones in its first five years, large scale implementation of DropoutJeep seems unlikely by close access methods.
The remarkable difference of AI today is its large scale implementation (mainstreaming ) into everyday life of every person.
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