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These inverse associations were observed only before knowledge of pregnancy, whereas they were attenuated toward the null after knowledge of pregnancy.
Before knowledge of pregnancy, acetaminophen was the most commonly (63%) used analgesic, followed by non-aspirin NSAIDs (31%) and aspirin (9%).
The frequency of use categories before knowledge of pregnancy included fewer than 5 times, 5 25 times, and more than 25 times.
Regular aspirin or non-aspirin NSAID users were more likely to be Caucasian and to drink during pregnancy, whereas regular acetaminophen users were less likely to use multivitamins before knowledge of pregnancy, compared with non-regular users.
In telephone interviews, mothers were asked whether they consumed vitamin supplements anytime in the year before or during the index pregnancy; in the year before pregnancy; early in but before knowledge of pregnancy; and after knowledge of pregnancy.
In our study, aspirin was used by 10.5% of controls and 8.5% of cases before knowledge of pregnancy, and by 3.7% of controls and 3.3% of cases after knowledge of pregnancy.
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Possible associations between infant leukaemia and maternal analgesic use, assessed both before and after knowledge of pregnancy, are shown in Table 2.
Analgesic questions included maternal use of aspirin, acetaminophen and non-aspirin NSAIDs, both before and after knowledge of pregnancy, including the frequency of use during these two time periods.
We also do not know if knowledge of pregnancy danger-signs of women developed before or after delivery.
However, the pregnancy of a co-worker -- a nurse herself, made me rethink my knowledge of pregnancy health altogether.
Women in the Copenhagen Pregnancy Cohort were encouraged to recall the time before they knew of their pregnancy, but were not specifically asked to distinguish between the period before and after, respectively, of knowledge of their pregnancy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com