However, multiple crossovers with randomly assigned treatment periods, with a complete random order or a random starting day may generate specific methodological problems and need new statistical models before being applicable in clinical drug testing.
Therefore, these interesting results needed to be duplicated in an independently run study and then validated in a large, independent, prospective trial, before being applicable in clinical practice [ 8].
However, the method still faces many challenges before it is applicable to an average laboratory of pathology.
In addition, compensation for occupational diseases stemming from historical exposures remains an issue [ 2], and in that case it is important to have well-quantified risk estimates, not least because of the general requirement in the UK and elsewhere that risk estimated from epidemiological studies should be demonstrably doubled before compensation is applicable.
While this is applicable before and at the beginning of outbreaks, reducing transmission in the midst of outbreaks or in endemic areas should consider a partially infected mosquito population.
Several technical challenges need to be addressed before the SECM probe is applicable for human imaging in vivo, however.
(Here I'd like to alert you all to a fabulous Twitter feed called TimGunnHaikus. A sample: Oh no! Second look?!?!/ Hey designers-have you not/ seen this show before?... which I think is applicable here as well).
We feel that more survival studies, following the criteria of Simon and Altman (1994), are needed before the estimation of lymphangiogenesis is applicable to clinical decision making and prognostication in melanoma patients.
However, additional technical and mathematical developments will be necessary before VE as a visualization tool is applicable for clinical routine in neurosurgical planning.
where is the average backoff value and is the average number of times that a node freezes its counter before reaches state 0. Equation (16) is applicable for both IB and BEB, however in IB it is given by.
