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These off-nominal events are opportunities to recognize potential accident pathogens, identify overlooked accident sequences, and make technical and organizational decisions to address them before further escalation can occur.
Six patients were entered at 2.0 mg/kg as an initial expansion cohort before further escalation, and six were entered at 3.5 mg/kg as a confirmatory expanded cohort of the highest planned dose after protocol revision.
If a DLT was observed in one of three patients at a given dose level, an additional three patients were enrolled at that dose level before further escalation was considered.
Similar(56)
But the way forward is not through escalating antagonism -- if further escalation is even possible at this point.
James had no interest in further escalation.
"We take the position that any further escalation is unacceptable".
Western pressure remains a powerful weapon: the coalition deal came just before a visit by America's vice-president.The agreement also makes NATO membership a goal, which Russia's deputy foreign minister warns could lead to further escalation.
The move represents a further escalation of the crisis between the countries.
Drugs advisers fear further escalation in the drugs war ahead of an election.
Another North Korean nuclear test could lead the Trump Administration to respond — and potentially further escalation.
"Nor will Russia be dislodged from Crimea nor deterred from further escalation by military force".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com